Every product from solutions to contact lens that have HydraGlyde have caused me major issues - eye irritation, dryness, etc. I originally encountered this when Clear Care added HydraGlyde to their cleaning solution. I switched during winter, hoping to get some relief for my dry eye. Received no relief and when winter ended, the dry eye did not. I finally got to searching around on the internet and discovered that other contact wearers were complaining of a sensitivity to HydraGlyde. Thinking this might be my issue, I returned to the Clear Care original formula and my dry eye mostly went away. Later, when I needed an extra pair of lens to make it through to my next eye appt, my doctor gave me a pair of sample lens - my normal brand, Air Optix for Astigmatism - that also contained HydraGlyde. Since it was not winter and my eyes were fairly stable from dry/allergies, I decided to test them out just to make sure that it all wasn't coincidence with my previous experience with HydraGlyde. I believe I went into it with an open mind, but by the end of the first day, I knew it was not going to work. My eyes were already a mess. I had kept my previous pair and was able to wear them for a couple of days while I cycled the new lens through Clear Care (non HydraGlyde) several times. After doing so, I could at least make it through most of the day before the new lenses became too irritating to wear. Alcon(probably when they were bought out by Novartis) changed their shipping solution a few years back, and I can no longer put contacts directly from the container into my eye (have been able to do that since I started wearing contacts in the early 80s), but after a soak in Clear Care overnight, I can wear the ones that do not contain HydraGlyde. HydraGlyde may be the best thing since peanut butter for some contact wearers, but I do hope Novartis sees that there is a significant number of users who cannot tolerate HydraGlyde and continues to make lenses with this additive.