Systane Ultra versus Systane Hydration PF

Comparison Highlights

Systane Ultra and Systane Hydration PF are popular eye drops used to relieve dryness and discomfort associated with various ocular conditions. Manufactured by Alcon, they contain polyethylene glycol 400 (0.4%) and propylene glycol (0.3%) as their active ingredients. They slightly differ in the composition of their wetting agents and lubricants with Systane Ultra utilizing POLYQUAD (polidronium chloride) as a preservative while Systane Hydration PF is preservative free and comes in small convenient one-time plastic vials. Both products contain hydroxypropyl guar, propylene glycol, and dimyristoyl phosphatidylglycerol for moisture, lubrication and protection.

Hydroxypropyl Guar: Hydroxypropyl guar is a polymer derived from guar gum, a natural substance extracted from guar beans. In eye drops, it acts as a thickening agent and provides a protective barrier on the surface of the eye, helping to retain moisture and lubricate the ocular surface. It enhances the time the eye drops stay on the eye's surface, prolonging their therapeutic effects.

Propylene Glycol: Propylene glycol is a synthetic compound commonly used in various pharmaceutical and cosmetic products, including eye drops. It helps to retain moisture in the eye and prevent dryness. Propylene glycol also has lubricating properties, which contribute to the soothing effect of eye drops. Additionally, it helps dissolve other active ingredients in the solution, ensuring their efficacy.

Dimyristoyl Phosphatidylglycerol: Dimyristoyl phosphatidylglycerol is a phospholipid, a type of lipid molecule found in cell membranes. In eye drops, it functions as a component that helps stabilize the tear film and maintain its integrity. The eye's lipid layer plays a crucial role in preventing tear evaporation and maintaining proper hydration of the ocular surface. Dimyristoyl phosphatidylglycerol contributes to the overall lubricating and moisturizing effects of eye drops, providing relief from dry eye symptoms.

Systane Ultra and Systane Hydration PF - Side-by-Side Specs

Systane Ultra

Systane Hydration PF

Product Image Systane Ultra Systane Hydration PF
Product Name Systane® Ultra Systane® Hydration PF
Type Lubricant Eye Drops Lubricant Eye Drops
Manufacturer Alcon Inc. Alcon Inc.
Release Date 2008 March 2020
FDA Device Class II II
Over the Counter (OTC) Yes Yes
Special Features
  • Preservative-free
  • HydroBoost Technology
Ingredients
Active Ingredients
  • Polyethylene glycol 400 0.4%
  • Propylene glycol 0.3%
  • Polyethylene glycol 400 0.4%
  • Propylene glycol 0.3%
Wettings Agents, Lubricants, Disinfectants
  • Aminomethyl propanol
  • Boric acid
  • Hydroxypropyl guar
  • Potassium chloride
  • Polyquaternium-1 - POLYQUAD® 0.001%
  • Sorbitol
  • Aminomethyl propanol
  • Boric acid
  • Hydroxypropyl guar
  • Sodium hyaluronate
  • Sorbitol
Aqueous Base with:
  • Hydrochloric acid
  • Sodium chloride
  • Sodium hydroxide
  • Hydrochloric acid
  • Potassium chloride
  • Sodium borate
  • Sodium chloride
  • Sodium hydroxide
Packaging, Pricing and Offers
Packaging Details 0.33 oz (10 ml)
Twin Pack 2 x 0.33 oz (2 x 10 ml)
30 vials 0.7ml (0.02 oz)
Price Range $14 - $18 (1 x 0.33 oz)
$22 - $26 (2 x 0.33 oz)
$17 - $22 per 30-pack
Cost per ounce (30ml) $33 - $39 per oz
(= $1.10 - $1.80 per ml)
$0.57 - $0.73 per vial
(= $0.81 - $1.05 per ml)
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