Biotrue Multi-Purpose Solution versus OPTI-FREE PureMoist

Biotrue Multi-Purpose Solution and OPTI-FREE PureMoist are two popular multi-purpose contact lens cleaning solutions. While both products provide dual-disinfection utilizing Polyquad as one of the main ingredients, Biotrue's Polyquad concentration is significantly reduced. Alcon's OPTI-FREE solution features HydraGlyde® Moisture Matrix, a technology known from the Air Optix with HydraGlyde contact lens family. Biotrue Multi-Purpose Solution's wetting agent is Hyaluronan (HA), an ingredient that wraps around the lens surface and captures moisture for up to 20 hours with a ph-value similar to the ph-value of human tears. The cost of using Biotrue or OPTI-FREE PureMoist is similar and you can get both products for as low as $0.80 per ounce when buying the 10oz twin pack.

What's the Same?

Before we dive into differences, let's have a quick look at the features these two multi-purpose cleaning solutions share.
Biotrue and OPTI-FREE PureMoist are the top-selling cleaning solutions offered by Alcon (OPTI-FREE PureMoist) and Bausch+Lomb (Biotrue). Both companies spend significant resources on the development and improvement of their contact lens cleaning products. Biotrue and OPTI-FREE PureMoist are both multi-purpose cleaning solutions suitable for SiHy and non-SiHy soft contact lenses. The term 'multi-purpose' means that they take on multiple tasks at once and make it more convenient for you to stick to a daily cleaning routine. They clean, disinfect, recondition and store your lenses and both products are time-tested as they were introduced in 2010 (Biotrue) and 2011 (OPTI-FREE PureMoist).


Manufacturers of cleaning solutions integrate several disinfectants and preservatives into their products. This is to kill a larger number of micro-organisms as they could be resistant to one disinfectant but not the other. Certain ingredients have shown effectiveness as a disinfectant in many studies and Biotrue and OPTI-FREE PureMoist are taking advantage of this: Both products utilize Polyquaternium (however Opti-Free contains 0.001% while Biotrue contains 0.0001% Polyquaternium), as well as boric acid and disodium EDTA. Also, both products use sodium chloride as a component for buffering and storage. As you may know, sodium chloride is salt, and when used in a 0.9% concentration it is very similar to the salt level in our tears.

Packaging and Cost

Both products can be purchased for as low as $0.80 per fluid ounce. The price range is quite wide and depends on the quantity you are buying. You are paying a premium when you don't buy a larger quantity such as a twin-pack with ten ounces per bottle compared to a small size bottle such as two ounces. The cost-per-ounce can be twice as much! So our recommendation: Once you have figured out the cleaning solution that works best for you, stick to it and buy the twin-packs.

What's Different?

Biotrue and OPTI-FREE Product Families

Bausch & Lomb's Biotrue product line-up is comprised of one product, while Alcon is offering three OPTI-FREE products: OPTI-FREE PureMoist, OPTI-FREE RepleniSH, and OPTI-FREE Express. And while they share the same family name, their ingredients and target markets are different.

OPTI-FREE Family Biotrue Family
Alcon - OPTI-FREE PureMoist Biotrue Multi-Purpose Solution
Alcon - OPTI-FREE RepleniSH  
Alcon - OPTI-FREE Express  

Disinfectants and Preservatives

A dual-disinfection system (which as the de-facto standard in multi-purpose cleaning solutions) can be found in both cleaning solutions and Polyquaternium (in different concentrations) is one of the components mentioned earlier. Besides, Bausch & Lomb is using Polyaminopropyl biguanide in a 0.00013% concentration while Alcon counts on their proprietary Aldox (0.0006% myristamidopropyl dimethylamine).

Wetting Agents and Lubricants

The most obvious difference between the two cleaning solutions is the type of wetting agent used to recondition the lenses. Biotrue contains hyaluronan, an ingredient that suggests (as studies have shown) to improve tear film volume and to stabilize the tear film. OPTI-FREE PureMoist's wetting agent is comprised of Tetronic 1304 (from BASF) and EOBO-41. By the way, Alcon brands this wetting technology as HydraGlyde which is also part of the latest version of their Air Optix products making them highly compatible with this cleaning solution.

Biotrue and OPTI-FREE PureMoist: Specs Compared

Biotrue Multi-Purpose Solution


Product Image Biotrue Multi-Purpose Solution OPTI-FREE PureMoist
Product Name Biotrue Multi-Purpose Solution OPTI-FREE® PureMoist®
Type Multi-Purpose Disinfecting Solution (MPDS) Multi-Purpose Disinfecting Solution (MPDS)
Manufacturer Bausch & Lomb Inc. Alcon Inc.
Release Date 2010 2011
FDA Device Class II II
Over the Counter (OTC) Yes Yes
Special Features With dual disinfection and a balanced pH value similar to your tears. Smart protein management using sulfobetaine keeps healthy tear proteins active. Featuring HydraGlyde® Moisture Matrix for all-day comfort and Dual Disinfection with Polyquad® and Aldox®
Disinfection & Preservatives
  • Polyaminopropyl biguanide 0.00013%
  • Polyquaternium-1 0.0001%

  • Boric acid
  • Disodium EDTA
  • Sulfobetaine
  • Aminomethyl propanol
  • Polyquaternium-1 - POLYQUAD® 0.001%
  • Myristamidopropyl dimethylamine - ALDOX® 0.0006%

  • Boric acid
  • Disodium EDTA
  • Sodium citrate
Wettings Agents & Lubricants
  • Hyaluronan (HA)
  • Poloxamine
  • Poloxamine - TETRONIC® 1304
  • Polyoxyethylene-poly-oxybutylene - EOBO-41®

  • Sorbitol
Buffer and Saline
  • Sodium borate
  • Sodium chloride
  • Sodium chloride
Packaging, Pricing and Offers
Packaging Details 2 oz (60 ml)
4 oz (118 ml)
10 oz (296 ml)
16 oz (473 ml)
Twin Pack 2 x 10 oz (2 x 296 ml)
Twin Pack 2 x 16 oz (2 x 473 ml)
2 oz (60 ml)
4 oz (120 ml)
10 oz (300 ml)
Twin Pack 2 x 10 oz (2 x 300 ml)
Price Range $9 - $14 (1 x 10 oz bottle)
$16 - $24 (2 x 10 oz twin pack)
$14 - $17 (1 x 10 oz bottle)
$16 - $26 (2 x 10 oz twin pack)
Cost per ounce (30ml) $0.80 - $1.40 (per oz) $0.80 - $1.70 (per oz)
Online Retailers info
Special Deals

Compare Prices

Special Deals

Compare Prices

Summary and Conclusion: Which Cleaning Solution Should You Get?

While you can buy both products over-the-counter and without prescription from your local drugstore or online, always discuss with your eye doc first whether these two products can be used with your contact lenses and whether they are right for you. Try both if you can. Buy a small two-ounce bottle of each, then use one product for a few days and the other for a few days after. While both products are multi-purpose cleaning solutions for soft contact lenses, they are quite different when you look at their disinfecting ingredients and the wetting agents they contain. And that could have an impact on the wearing comfort of your lenses. Some people will find their lenses to be more comfortable after cleaning them with Biotrue rather than with OPTI-FREE PureMoist and vice versa. We are all unique and so are our eyes and how they respond to the chemicals in contact lenses and cleaning solutions.

References and Clinical Studies